Induction of interleukin-1b, tumour necrosis factor-a and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan
نویسندگان
چکیده
Department of Clinical Microbiology and Infectious Diseases, The Hebrew University—Hadassah Medical Center, PO Box 12000, Jerusalem 91120, Israel; Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC 27709, USA; Department of Medicinal Chemistry and Natural Products, The Hebrew University of Jerusalem—School of Pharmacy, PO Box 12065, Jerusalem, Israel
منابع مشابه
Induction of interleukin-1beta, tumour necrosis factor-alpha and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan.
OBJECTIVES To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters...
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